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DDInter 2.0: an enhanced drug interaction resource with expanded data coverage, new interaction types, and improved user interface

January 2025 Yao Tian, Jiacai Yi, Ningning Wang, Chengkun Wu, Jinfu Peng, Shao Liu, Guoping Yang, Dongsheng Cao Nucleic Acids Research
Drug Interaction Clinical Informatics Knowledge Base Web Resource

Drug interactions pose significant challenges in clinical practice, potentially leading to adverse drug reactions, reduced efficacy, and even life-threatening consequences. DDInter 2.0 substantially expands data coverage with over 0.36M interaction associations among 3,130 entities, introduces new interaction types including drug-food and drug-disease interactions, and features a redesigned user interface with enhanced visualization and retrieval capabilities. The platform integrates severity classification, mechanistic annotations, and clinical management strategies to support safer polypharmacy decision-making.