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DDInter: an online drug-drug interaction database towards improving clinical decision-making and patient safety

January 2022 Guoli Xiong, Zhijiang Yang, Jiacai Yi, Ningning Wang, Lei Wang, Huimin Zhu, Chengkun Wu, Aiping Lu, Xiang Chen, Shao Liu, Tingjun Hou, Dongsheng Cao Nucleic Acids Research
Drug Interaction Database Clinical Decision Making

Drug-drug interaction (DDI) can trigger many adverse effects in patients and has emerged as a threat to medicine and public health. We present DDInter, a curated DDI database with comprehensive data, practical medication guidance, intuitive function interface, and powerful visualization. DDInter contains about 0.24M DDI associations connecting 1,833 approved drugs. Each interaction is annotated with severity, mechanism description, management strategies, and alternative medications. A prescription checking function is provided to help clinicians decide whether drug combinations can be used safely.